Fig. 9: Ribbon representations of long time-scale simulations of the apo AT1 receptor in SOPC membranes using the CHARMM36 FF on the Anton 2 supercomputer. | Nature Communications

Fig. 9: Ribbon representations of long time-scale simulations of the apo AT1 receptor in SOPC membranes using the CHARMM36 FF on the Anton 2 supercomputer.

From: Membrane mediated mechanical stimuli produces distinct active-like states in the AT1 receptor

Fig. 9

a Structure after 20 μs with a tension of 10 mN/m compared to the active state crystal structure (PDBID: 6OS0, with AngII-bound). b Structure after 5 μs with no tension compared to inactive state crystal structure (PDBID: 4YAY, with antagonist-bound). Structures superimposed by minimizing the RMSD distance.

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