Table 1 Correlation of estimated to true cell type proportions in Mouse cortex data

	SONAR	SONAR-0	CARD	RCTD	Cell2location	Stereoscope	SPOTlight	SpatialDWLS	SD2
Olig	0.957	0.960	0.960	0.956	0.953	0.955	0.912	0.947	0.877
Excitatory L2/3	0.885	0.884	0.549	0.878	0.766	0.678	0.850	0.400	0.532
Inhibitory Sst	0.851	0.828	0.756	0.819	0.489	0.839	0.503	0.712	0.262
Excitatory L4	0.826	0.840	0.646	0.865	0.828	0.872	0.795	0.723	0.349
Excitatory L6	0.824	0.840	0.785	0.810	0.838	0.723	0.836	0.699	0.458
Astro	0.789	0.799	0.592	0.778	0.743	0.772	0.748	0.682	0.425
Excitatory L5	0.711	0.726	0.515	0.706	0.654	0.561	0.552	0.453	0.172
Inhibitory Pvalb	0.627	0.670	0.659	0.696	0.709	0.779	0.627	0.585	0.371
Endo	0.586	0.584	0.584	0.599	0.527	0.557	0.424	0.384	0.174
Inhibitory Vip	0.572	0.566	0.332	0.310	0.400	0.426	0.431	0.294	0.324
Smc	0.515	0.130	0.599	0.270	0.138	−0.144	−0.144	−0.112	−0.044
Micro	−0.060	−0.053	−0.132	−0.062	−0.031	−0.034	−0.050	−0.069	0.052
Average	0.673	0.648	0.570	0.635	0.585	0.582	0.540	0.493	0.329

The value indicates the Pearson correlation of estimated to true cell type proportions for each cell type for all algorithms. Higher values indicate better performance. The top two correlations for each cell type are shown in bold.

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