Fig. 6: Functional support of putative AF risk genes.
From: Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation
a Log-normalized CM expression of genes at PIP ≥ 0.8 vs. other genes from the AF loci (n = 580 for control genes and n = 42 for genes at PIP ≥ 0.8). The center line of a box represents the median; the lower and upper hinges of a box correspond to the first and third quartiles; the upper/lower whisker extends from the hinge to the largest/smallest value no further than 1.5× inter-quartile range from the hinge. b Percentage of Mendelian disease genes from OMIM in each gene PIP bin. c Top 5 Biological Processes (BP) and Molecular Functions (MF) GO terms from gene-set enrichment analysis of the 46 genes with PIP ≥ 0.8. d Gene interaction network of candidate AF genes (PIP ≥ 0.5) using STRING. Only genes with interactions are shown. Interactions are defined using a confidence threshold of 0.7 by STRING. Node sizes represent gene PIPs. Colors of genes indicate their shared molecular functions.
