Fig. 6: Activation of LRRK1 by mutation of Y971, and location in the structure.
From: Structure and regulation of full-length human leucine-rich repeat kinase 1
A Effect of Y971 substitution mutations. Results presented are the quantification of multiple kinase assays from at least three independent protein preparations (see “Methods”, Supplementary Fig. 9E for representative membrane images and Supplementary Fig. 10 for complete membrane images, values are mean ± SEM, n = 6–36 independent assays from 9 independent protein preparations (WT, K1270M, Y971F) or 3 independent protein preparations (all other mutants)). B Structure of LRRK1, with the position of Y971, and the Roc and the COR-A domains indicated. C Location of Y971 in the COR-A domain relative to the Switch-I motif and the bound GDP in the Roc domain. D Cryo-EM density supporting the position of Y971. In D the map shown is the composite cryo-EM density map. Source data is provided as a source data file.
