Fig. 1: In vitro antiviral activity of nirmatrelvir. | Nature Communications

Fig. 1: In vitro antiviral activity of nirmatrelvir.

From: Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

Fig. 1: In vitro antiviral activity of nirmatrelvir.The alternative text for this image may have been generated using AI.

a Structure of nirmatrelvir. b Nirmatrelvir dose-response assays against SARS-CoV-2 WA1, and lineages B.1.1.7 (VOC α), B.1.351 (VOC β), P.1 (VOC γ), B.1.617.2 (VOC δ), B.1.1.529, BA.2, B1.2.12.1, and BA.4 on VeroE6-TMPRSS2 cells. The number of independent repeats (n) used in each experiment is shown (n = numbers of biologically independent samples). Symbols represent, and lines intersect, group geometric means ± SD; numbers denote 50 and 90% inhibitory concentrations (EC50 and EC90, respectively), determined through non-linear 4-parameter variable slope regression modeling. Source data are provided as a Source data file.

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