Table 1 Single dose pharmacokinetics of nirmatrelvir or nirmatrelvir/ritonavir in Roborovski dwarf hamster and human plasma
Drug | Species | Dose (mg/kg) | Tmax (h) | Cmax (ng/ml) | AUCinf (hours × ng/ml) | t1/2 (h) | Reference |
|---|---|---|---|---|---|---|---|
Nirmatrelvir/ ritonavir | Roborovski dwarf hamster | 250/83 | 1 | 34,200 | 215,000 | 2.21 | This study |
Nirmatrelvir | Roborovski dwarf hamster | 250 | 1 | 5320 | 22,400 | 1.36 | This study |
Nirmatrelvir/ ritonavir | Human | 250/100a | 2.75 | 2882 | 28,220 | 6.94 | |
Molnupiravir | Human | 800a | 1.75 | 2770 | 8200 | 1.18 | |
Molnupiravir | Roborovski dwarf hamster | 250 | 0.5 | 251 | 376 | 1.62 |
