Table 2 Single dose pharmacokinetics of nirmatrelvir/ritonavir in ferret and human plasma
Drug | Species | Dose (mg/kg) | Tmax (h) | Cmax (ng/ml) | AUCinf (hours × ng/ml) | t1/2 (h) | Reference |
|---|---|---|---|---|---|---|---|
Nirmatrelvir/ritonavir | Ferret | 20/6 | 2.33 | 8990 | 32,700 | 1.05 | This study |
Nirmatrelvir/ritonavir | Ferret | 100/6 | 4 | 11,800 | 49,500 | 0.74 | This study |
Nirmatrelvir/ritonavir | Human | 250/100a | 2.75 | 2882 | 28,220 | 6.94 | |
Molnupiravir | Human | 800a | 1.75 | 2770 | 8200 | 1.18 | |
Molnupiravir | Ferret | 4 | 1.7 | 907 | 3421 | 8.2 | |
Molnupiravir | Ferret | 7 | 1.5 | 2851 | 7569 | 9.2 | |
Molnupiravir | Ferret | 20 | 1.8 | 3992 | 18,793 | 4.7 | |
Molnupiravir | Macaque | 130 | 1.62 | 2644 | 25,299 | 1.77 |
