Fig. 3: Impact of omicron infection on secretory IgA and ability to inhibit ACE2 binding to spike proteins in nasal lining fluid in vaccinated SARS-CoV-2-naive and previously-infected individuals. | Nature Communications

Fig. 3: Impact of omicron infection on secretory IgA and ability to inhibit ACE2 binding to spike proteins in nasal lining fluid in vaccinated SARS-CoV-2-naive and previously-infected individuals.

From: Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history

Fig. 3: Impact of omicron infection on secretory IgA and ability to inhibit ACE2 binding to spike proteins in nasal lining fluid in vaccinated SARS-CoV-2-naive and previously-infected individuals.

Secretory IgA (sIgA) in nasal lining fluid targeting a ancestral, BA.1, BA.2, and BA.4 spike proteins and b nucleocapsid protein, expressed as area under the curve (AUC) normalized to total sIgA; c ability of nasal lining fluid to inhibit ACE2 binding to ancestral, BA.2 and BA.5 spike proteins, assessed by MSD assay. Data are shown with median and interquartile range. Median fold-change from pre- to post-infection is displayed. Statistical comparisons of paired pre- and post-infection samples made with two-sided Wilcoxon-signed-rank test, and between post-infection levels in previously-infected and SARS-CoV-2 naive individuals made with two-sided Mann–Whitney U-test. p-values are displayed where <0.05. Responses were evaluated in 32 SARS-CoV-2-naive and 19 previously-infected individuals for whom samples were available. Source data are provided as a Source Data file.

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