Fig. 9: Applications of nickel-catalysed amidation.
From: Streamlining the synthesis of amides using Nickel-based nanocatalysts
a Synthesis of selected drugs. Reaction conditions: 0.5 mmol nitro compound, 1 mL ester, 30 mg Ni-L1@TiO2-800, 20 mg TiO2, 20 bar H2, 130 °C, 24 h. Isolated yields based on nitro compound. b Amidation of nitro and ester containing drugs. Reaction conditions: 0.5 mmol nitro compound, 1 mL ester, 30 mg Ni-L1@TiO2-800, 20 mg TiO2, 20 bar H2, 130 °C, 24 h. Isolated yield based on nitro compound. c Scale-up reactions. +Reaction conditions: 10 g nitro compound, 30 mL ethyl acetate, required amount of catalyst and TiO2 (30 mg of Ni-L1@TiO2-800 and 20 mg TiO2 for each 0.5 mmol nitro compound), 20 bar H2, 130 °C, 24 h. Δ1.2 g nitro compound, 4 mL ethyl acetate, required amount of catalyst and TiO2 (30 mg of Ni-L1@TiO2-800 and 20 mg TiO2 for each 0.5 mmol nitro compound), 20 bar H2, 130 °C, 24 h. Isolated yields based on nitro compound. The detailed information of these esters is provided in Supplementary Fig. 22.
