Fig. 6: ChIP-seq of BLM-treated alveolar organoids suggests that p53 indirectly induces TGF-β signaling. | Nature Communications

Fig. 6: ChIP-seq of BLM-treated alveolar organoids suggests that p53 indirectly induces TGF-β signaling.

From: Autocrine TGF-β-positive feedback in profibrotic AT2-lineage cells plays a crucial role in non-inflammatory lung fibrogenesis

Fig. 6

a p53 bindings at TGF-β related genes and Cdkn1a (a positive control). b Enriched pathways of genes targeted by p53 in BLM-treated alveolar organoids (AOs) analyzed by “MSigDB Hallmark 2020”. A total of 1425 genes that showed significantly higher peaks in BLM-AOs (compared to CTRL-AOs) were evaluated. Data were obtained from two independent wild-type mice. c Venn diagram of the genes with higher peaks in ChIP-seq and those with higher mRNA expressions in RNA-seq in BLM-AOs (compared to CTRL-AOs).

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