Fig. 3: Salivary-specific activation of selected genes in the Casein locus by the super-enhancer. | Nature Communications

Fig. 3: Salivary-specific activation of selected genes in the Casein locus by the super-enhancer.

From: Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands

Fig. 3

a Expression of the five Casein genes, Odam and Fdcsp genes was measured by RNA-seq in salivary tissue from ΔSE mice (n = 3). Results are shown as the means ± SEM of independent biological replicates. p-values are from 2-way ANOVA followed by Sidak’s multiple comparisons test between WT and mutants. **p < 0.01, ****p < 0.0001. b ChIP-seq analysis shows the H3K27ac and Pol II landscapes in salivary tissue from WT mice and mice lacking the super-enhancer (ΔSE). The red shade indicates the super-enhancer (SE). The red shade indicates the super-enhancer. The Cish locus served as ChIP-seq control. MG, mammary gland at day one of lactation (L1). Source data are provided as a Source Data file.

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