Fig. 2: Overall structure of dog apo HSD17B13.

a, b Ribbon diagrams of dog apo HSD17B13 dimer, with subunits colored green and cyan. The HSD17B13 dimer model was oriented with the putative membrane anchoring domains (tubes) down toward a phospholipid membrane. A gray dashed line is drawn to show the position of the membrane surface. The N- and C- termini as well as residues marking the boundaries of the membrane anchoring N-helix and helix-turn-helix are labeled for one subunit. b To highlight the membrane associating domains of the HSD17B13 dimer, the view is slightly tilted upwards relative to a. c, d surface electrostatic presentations of HSD17B13 dimer. Blue, red, and white represent positive, negative, and neutral surfaces, respectively. The view in c is the same as in a. The view in d is the same as in b.