Fig. 8: “Lid 3” dictates the donor nucleotide specificity of CD-NTases. | Nature Communications

Fig. 8: “Lid 3” dictates the donor nucleotide specificity of CD-NTases.

From: Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases

Fig. 8

(A) Summary of the specificity-determining residues for donor nucleotides of CD-NTases in different clades. (B–E) Left, the sequence logo of lid 3 of (B) CdnA01, (C) CdnB04, (D) CdnC01 and (E) CdnG10. The residues forming direct interaction with donor nucleotide are indicated by arrows. Right, the enlarged view of the donor pocket of the representative of (B) CdnA01 (VcDncV, PDB 4XJ3), (C) CdnB04 (BfCdnB, PDB 7LJO), (D) CdnC01 (EcCdnC, PDB 6P80), (E) CdnG10 (BdCdnG, PDB 7LJN). The bound donor nucleotide, lid 2 and 3 are shown in sticks.

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