Fig. 6: Radioprotection of CHDV alleviates radiation colitis. | Nature Communications

Fig. 6: Radioprotection of CHDV alleviates radiation colitis.

From: A ferroptosis-targeting ceria anchored halloysite as orally drug delivery system for radiation colitis therapy

Fig. 6

a Schematic illustration for in vivo radioprotection evaluation. b Body weight of mice (n = 6). c Survival curves at day 30 (n = 10), the data were analyzed by Log-rank test. P < 0.0001 vs the X-ray group. d Representative photographs of the wet tail and hematochezia on day 7 in various groups. e DAI of radiation colitis, f diarrhea index, and g hematochezia index in each group (n = 10). h Representative photographs of H&E staining of colon tissue after 7 days of treatment. Scale bars, 1 mm. The experiment was repeated six times independently with similar results. i The activity of MPO in colon tissue (n = 5). j The gene expressions of Cxcl1, Tnf-α, and Il6 in colon tissue were detected by the q-PCR assay (n = 3), and k they were quantified and visualized by heatmap. The data are represented as mean ± SD. The data were analyzed by one-way ANOVA with Tukey’s post hoc test. Source data are provided as a Source Data file.

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