Table 1 Antibacterial activity of CEF in the absence and presence of different metal compounds against different bacteria

From: Metallo-sideromycin as a dual functional complex for combating antimicrobial resistance

 

MIC of CEF (μM)

In the presence of 50 μM of metal compounds

Strains

Alone

Bi3+

Ga3+

Co3+

Cr3+

Fe3+

Mn2+

Ti4+

P. aeruginosa PAO1

4

0.06

0.06

4

4

4

8

4

P. aeruginosa PA14

4

0.12

0.06

4

4

8

8

4

P. aeruginosa ATCC27853

2

0.12

0.12

4

4

4

4

4

B. cepacia ATCC25416

2

0.03

0.06

4

2

2

4

2

B. cepacia J2315

0.5

0.03

0.03

4

0.5

0.5

0.5

0.5

E. coli ATCC25922

1

1

1

1

1

2

2

1

E. coli ATCC10536

0.03

0.03

0.03

0.125

0.03

0.06

0.06

0.03

E. coli (NDM-1)+

1

1

1

2

1

2

4

2

E. coli clinical

1

1

1

1

1

1

1

1

  1. Metal compounds used are: Bi3+—colloidal bismuth citrate (CBS); Ga3+—Ga(NO3)3 (or GaNit); Co3+—Co(OAc)3; Cr3+—Cr2(SO4)3; Fe3+—FeCl3; Mn2+—Mn(OAc)2; Ti4+—Ti(IV)-citrate.
  2. CEF cefiderocol, MIC minimum inhibitory concentration.