Fig. 1: Schematic illustration of Janus Dex-BSe nanoparticles for flexible elimination of biofilms. | Nature Communications

Fig. 1: Schematic illustration of Janus Dex-BSe nanoparticles for flexible elimination of biofilms.

From: Janus nanoparticles targeting extracellular polymeric substance achieve flexible elimination of drug-resistant biofilms

Fig. 1

Janus Dex-BSe nanoparticles are prepared by a nonsolvent-aided counterion complexation strategy. Benefiting from EPS targeting of dextran domain, Janus Dex-BSe nanoparticles could target and penetrate biofilms, further achieving synergistic effects between dextran and BSe components. As a result, efficient biofilm dispersion can be realized by enhanced gene up-regulation, which is employed in wound dressings to remove drug-resistant MRSA biofilm efficiently. Alternatively, biofilm accumulation can be realized after the intravenous injection of Janus nanoparticles. After NIR light irradiation is applied, enhanced photothermal effect induced by the active motion enables photothermal killing to eradicate the biofilm in the MRSA-infected abscess model.

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