Fig. 1: The unfolding and aggregation process of insulin and its adhesive behavior based on MD simulation.
From: Synthesis of robust underwater glues from common proteins via unfolding-aggregating strategy
a The unfolding of insulin in a TFE aqueous solution (80%) after cleavage of the disulfide bonds. b Aggregation of the unfolding insulin chains in water with TFE on their surface. c The adhesive behavior of unfolded insulin between two layers of silica. d Snapshot, pull force curve and second structural development of unfolded insulin in the steered MD simulation. Silica bonded by the unfolded insulin chain was subjected to a pull force in the direction parallel to the silica sheets.
