Fig. 3: Estimates of genetic, interaction, and environment (WHR) R2.
Estimates were computed for eleven outcomes with associated directionality of effects using the MonsterLM methodology. a Genetic, interaction, and environment (WHR) variance estimated \({R}^{2}\) for each outcome using the MonsterLM protocol. Estimates and 95% confidence intervals are represented by dot and whisker plots. b The directionality of effects for derived interaction estimates. SNPs were filtered based on univariate \({P}_{G}\), \({P}_{{GE}}\) and LD (r2 < 0.1) for each outcome. Directionality is concordant when \({\hat{\beta }}_{G}\) and \({\hat{\beta }}_{{GE}}\) have the same sign (+/+, −/−) and discordant when they have opposite signs (+/−, −/+). Two-proportion Z-tests were used to compare each directionality result with a null value of 0.5. Two-sided significance was defined as p < 0.05. Directionality was computed only for significant outcomes. Estimates were conducted with 325,989 individuals and 1,030,579 SNPs after quality control. Source data are provided as a Source Data file.
