Table 1 Real data estimates for continuous outcomes with MonsterLM

From: A versatile, fast and unbiased method for estimation of gene-by-environment interaction effects on biobank-scale datasets

Trait

Additive genetic variance (95% CI)

WHR GxE variance (95% CI)

M10 GxE variance (95% CI)

Smoking GxE variance (95% CI)

Permuted exposure GxE (95% CI)

Apolipoprotein A

0.281 (0.271, 0.290)

0.0236 (0.014, 0.033)

0.007 (−0.003, 0.017)

0.000739 (−0.0193, 0.0207)

−0.0027 (−0.0127, 0.0073)

Apolipoprotein B

0.219 (0.210, 0.228)

0.0242 (0.016, 0.033)

0.040 (0.030, 0.050)

0.00984 (−0.0102, 0.0298)

−0.0038 (−0.0134, 0.0062)

Total Cholesterol

0.179 (0.170, 0.188)

0.0183 (0.010, 0.027)

0.042 (0.032, 0.052)

0.00505 (−0.0150, 0.0251)

0.0000 (−0.0099, 0.0099)

CRP

0.238 (0.229, 0.247)

0.0711 (0.063, 0.080)

0.028 (0.018, 0.038)

0.0100 (−0.010, 0.030)

−0.0022 (−0.0122, 0.0078)

Glucose

0.105 (0.096, 0.115)

0.00475 (−0.004, 0.014)

0.003 (−0.007, 0.013)

0.00776 (−0.0122, 0.0278)

−0.0007 (−0.0106, 0.0092)

HDL-Cholesterol

0.313 (0.303, 0.323)

0.0380 (0.029, 0.047)

0.010 (0.001, 0.020)

−0.00234 (−0.0223, 0.0177)

−0.0020 (−0.0120, 0.0080)

HbA1c

0.289 (0.280, 0.299)

0.00884 (0.000, 0.018)

0.013 (0.003, 0.023)

0.00610 (−0.0139, 0.0261)

−0.0010 (−0.0110, 0.0006)

Height

0.683 (0.674, 0.694)

0.00136 (−0.007, 0.010)

0.0047 (−0.005, 0.015)

−0.00124 (−0.0212, 0.0188)

−0.0013 (−0.0089, 0.0063)

LDL-Cholesterol

0.173 (0.164, 0.182)

0.0194 (0.011, 0.028)

0.045 (0.035, 0.055)

0.00825 (−0.0118, 0.0283)

0.0014 (−0.0085, 0.0114)

Triglycerides

0.205 (0.196, 0.213)

0.0680 (0.061, 0.077)

0.024 (0.014, 0.034)

0.00696 (−0.0130, 0.0270)

−0.0006 (−0.0106, 0.0094)

Total Bilirubin

0.399 (0.389, 0.408)

0.000634 (−0.008, 0.009)

0.002 (−0.007, 0.012)

0.00498 (−0.0150, 0.0250)

−0.0019 (−0.0119, 0.0081)

  1. MonsterLM real data results for continuous outcomes. Presented are real data estimates for continuous outcomes. All estimates are performed using the MonsterLM methodology. Exposures include waist-hip-ratio (WHR), number of days of 10 minutes moderate exercise (M10), dichotomous smoking status (Smoking), and permuted exposure (Epm). Bolded estimates are significant.
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