Fig. 3: Neutralization activity of HH-120 against SARS-CoV-2 and other coronaviruses.
From: An IgM-like inhalable ACE2 fusion protein broadly neutralizes SARS-CoV-2 variants
a Neutralization of pseudotyped viruses (lentivirus or VSV system) of the SARS-CoV-2 D614 strain, the G614 strain, SARS-CoV, Pangolin-CoV, Delta (B.1.617.2) variant, Omicron (B.1.1.529, BA.1.1, BA.2, BA.2.12.1, BA.4 or BA.5, BA.2.75, BA.2.76, BF.7, XBB, BQ.1.1) variants by HH-120. Pseudotyped viruses were incubated with serially diluted HH-120 (1.5–10,000.0 ng/mL), then inoculated with 293T-hACE2 cells. Results shown are representative data of at least two independent experiments, except for the Pangolin-CoV pseudotyped virus. Data shown are average values of two replicates from distinct samples, except for the Pangolin-CoV pseudotyped virus without replicates. b Neutralization of SARS-CoV-2 authentic virus of ancestral strain (EPI_ISL_402119), Alpha, Beta, Delta, Omicron (XBB.1.16 and B.1.1.529 sublineages) variants by HH-120. Vero cells or HK-2 cells were used as host cells. Results shown are representative data of at least two independent experiments. Data shown are average values of three replicates from distinct samples. Error bars represent the SD. Cells without virus infection were used as assay blanks; calculated IC50 and IC90 values were determined using 4-parameter logistic regression (a, b). Source data are provided as a Source Data file.
