Fig. 3: LKO mice have altered plasma lipid levels and lipoprotein profile.
From: Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans
Plasma was collected from 8-week-old control and LKO (a, d, c, f) male (n = 8 mice/group) and (b, e) female mice (n = 6 mice/group). The level of (a, b) total cholesterol (p-value male and female <0.0001) and (d, e) triglycerides was determined as shown. c, f Plasma was collected from control and LKO male mice (n = 8/group) and divided to 4 pools (n = 2/pool). Each pool was fractionated individually and the (c) cholesterol and (f) triglyceride content was continuously measured. The plotted line depicts the average cholesterol or triglyceride levels. (a, b, d, e) Box plots show the median (middle line), 25th, 75th percentile (box) and minimum and maximum values (whiskers). ***p < 0.001 analyzed by (a, b, d, e) two-tailed Welch’s t-test. Source data are provided as a Source Data file.
