Fig. 6: Genetic associations of variants in the SPRING gene locus with plasma lipids and biomarkers.
From: Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans
a Locus zoom of genetic associations of variants in the SPRING locus (12q24.22) with HDL cholesterol. Each variant identified in the 1000 genomes project is represented by a triangle, with color representing linkage disequilibrium (LD) with the lead SNP (rs10507274, purple diamond). A single variant, rs10507274, demonstrates the most significant association with HDL cholesterol plasma levels (p = 8.656e-11). b Genetic associations of rs10507274 with plasma lipids and lipoproteins in the Global Lipids Genetics Consortium dataset. Effects on circulating total cholesterol, LDL-C, non-HDL-C, HDL-C, and triglycerides are plotted per rs10507274-C allele. Each point and error represent the beta value ± SE. Corresponding beta, standard error p values, and number of individuals are shown on the right. c Genetic associations of rs10507274 with plasma lipids, lipoproteins and apolipoproteins in the UK-Biobank. Effects on circulating total cholesterol, LDL-C, HDL-C, triglycerides, Apolipoprotein A1, B, and lipoprotein (a) are plotted per rs10507274-C allele. Each point and error represent the beta value ± SE. Corresponding beta, standard error, p values and number of individuals are shown on the right.
