Fig. 6: Cbfβ2 expression regulates the induction of CD4⁺CD8αα⁺ IELs.

a Surface CD8α and intracellular Foxp3 expression of TCRβ⁺CD4⁺CD8β^– SI IELs from Cbfb^+/+ and Cbfb^2m/2m mice. b Graphs show the frequency of CD8α⁺ or Foxp3⁺ populations among TCRβ⁺CD4⁺CD8β^– cells in SI IELs. (n = 7 mice for Cbfb^+/+ group, n = 5 mice for Cbfb^2m/2m group, 10 weeks old). Data are expressed as mean ± SEM. c Surface CD8α and intracellular Foxp3 expression by TCRβ⁺CD4⁺CD8β^– cells in SI IELs of Rosa26^{lsl-Cbfb2-GFP} and CD4^Cbfb2Tg mice analyzed at 7 and 10 weeks of age. d Graphs show the frequency of CD8α⁺ or Foxp3⁺ populations among TCRβ⁺CD4⁺CD8β^– SI IELs of Rosa26^{lsl-Cbfb2-GFP} and CD4^Cbfb2Tg mice (7W; n = 3 mice for each group, 10W; n = 5 mice for Rosa26^{lsl-Cbfb2-GFP} group, n = 4 mice for CD4^Cbfb2Tg group). Data are expressed as mean ± SD. The two-sided Student’s t test (b, d) was applied. Source data are provided as a Source data file.