Fig. 5: Functional breadth across hCoV is imprinted by vaccination or infection history. | Nature Communications

Fig. 5: Functional breadth across hCoV is imprinted by vaccination or infection history.

From: SARS-CoV-2 vaccination elicits broad and potent antibody effector functions to variants of concern in vulnerable populations

Fig. 5: Functional breadth across hCoV is imprinted by vaccination or infection history.

A Functional breadth in vaccinated (n = 87) (green), convalescent (n = 57) (blue), and naïve (n = 37) (black) subjects in phagocytosis (top), ADCC (center), and complement deposition (bottom) as defined by the geometric mean of each activity directed to spike (left) and RBD (right) across variants. Bar indicates mean, and whiskers indicate interquartile range. Statistical significance was defined by ANOVA Kruskal–Wallis test with Dunn’s correction and α = 0.05 (****p < 0.0001). B, C. Phagocytosis (top), ADCC (center), and complement deposition (bottom) activities observed in vaccinated (n = 87) (green) and convalescent (n = 57) (blue) subjects across other emergent (B) and endemic (C) CoV spike antigens consisting of unstabilized (S) stabilized (S2P) and S1 or S2 subdomains of spike from indicated hCoV strains. Statistical differences were measured by the Mann–Whitney test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). Bars indicate the mean, and whiskers indicate the standard deviation. Functional activity is reported in arbitrary units (AU), relative light units (RLU), and median fluorescent intensity (MFI).

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