Fig. 3: Transcranial acoustic simulations in a representative individual.

a Pseudo-CT (right) derived from T1-weighted MRI (left) used to estimate skull acoustic properties. b Simulated ultrasound pressure field overlaid on the T1-weighted MRI showing reliable targeting of the dorsal anterior cingulate cortex (dACC) and posterior cingulate cortex (PCC). c Simulated transcranial ultrasound stimulation (TUS) focal pressure volumes shown with the 2 × 2 × 2 cm3 MRS voxels for each session (sham in blue, PCC TUS in red and dACC TUS in green) in a representative individual. MPa megapascal.