Fig. 1: Scopolamine impairs episodic memory encoding.
From: Acetylcholine modulates the temporal dynamics of human theta oscillations during memory
a Diagram of the task structure: prior to the task, subjects received a single dose of scopolamine (or saline, in a placebo condition). During the encoding period of the task, subjects are presented with a sequence of twelve words. Then, after completing a math distractor consisting of simple algebra equations, subjects are asked to verbally recall as many words as possible from the encoding period. b Bar plot showing differences in recall probability between the placebo and scopolamine sessions for all subjects (t(12) = 6.19, p = 6.79 × 10−5, two-sided paired t-test). c Percent decrease in recall probability with respect to the placebo session for all subjects. d Bar plot showing differences in accuracy in the math distractor between the placebo and scopolamine sessions (t(12) = 0.42, p = 0.68, two-sided paired t-test). e Recall probability by word serial position during encoding. Data are presented as mean values across subjects, and error bars indicate the 95% confidence interval. f Probability of first recall (PFR) by word serial position during encoding. Data are presented as mean values across subjects, and error bars indicate the 95% confidence interval. g Conditional response probability (CRP). Data are presented as mean values across subjects, and error bars indicate the 95% confidence interval. Source data are provided as a source data file.
