Fig. 8: A working model outlining the proposed mechanism. | Nature Communications

Fig. 8: A working model outlining the proposed mechanism.

From: Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling

Fig. 8

Under HFHS diet condition, HDCA intervention ameliorates NAFLD by inhibiting the formation of nucleus-cytoplasm shuttling heterotrimer, RAN/CRM1/PPARα, through direct binding with RAN protein, resulting in increased nuclear localization of PPARα and activated fatty acid oxidation. Created with BioRender.com.

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