Fig. 3: P199L severely disrupts ERG transforming capacity in vivo. | Nature Communications

Fig. 3: P199L severely disrupts ERG transforming capacity in vivo.

From: The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG

Fig. 3: P199L severely disrupts ERG transforming capacity in vivo.The alternative text for this image may have been generated using AI.

A Survival analysis of C57B/6 mice transplanted with murine fetal liver-derived HSPC following transduction with ERG variants (105 transduced cells/mouse). A log-rank test was used to compare survival distribution between groups. The P-value comparing WT-ERG vs. P199LERG is P < 0.0001. * denotes P ≤ 0.05, ** denotes P ≤ 0.01, *** denotes P ≤ 0.001, **** denotes P ≤ 0.0001. B Immunoblot of HA-tagged ERG to compare the levels of protein expression of WT and mutated ERG in the spleen of leukemic mice. C Immunophenotype of AML blasts (GFP+) from the bone marrow of leukemic mice. Source data are provided as a Source Data file.

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