Fig. 4: P199L impedes ERG-mediated transcriptional gene repression in HSPC. | Nature Communications

Fig. 4: P199L impedes ERG-mediated transcriptional gene repression in HSPC.

From: The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG

Fig. 4: P199L impedes ERG-mediated transcriptional gene repression in HSPC.The alternative text for this image may have been generated using AI.

A Pathway and functional analysis of the gene expression profile of ERG variants against BB was performed using GSEA. Molecular pathways related to down and upregulated genes are presented separately. The absence of a circle implies no statistical significance enrichment for a particular gene set. A positive enrichment score refers to upregulated genes, and a negative score refers to downregulated genes (ERG variants against the backbone). The percentage of hits (“tags” in leading-edge analysis) is displayed to indicate the percentage of genes contributing to the enrichment score for each set of genes. B GSEA of upregulated genes (P199L-ERG against WT-ERG). C Most significant DEG (Padj < 0.05) contributing to the enrichment scores in A are shown for representative sets (ERG variants against BB). HSPC—hematopoietic stem and progenitor cells, LSC—leukemic stem cells. NES—Normalized enrichment score. DEG—differentially expressed genes. BB—backbone. Source data are provided as a Source Data file.

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