Fig. 5: P199L disrupts the interaction of ERG with chromatin modifiers. | Nature Communications

Fig. 5: P199L disrupts the interaction of ERG with chromatin modifiers.

From: The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG

Fig. 5: P199L disrupts the interaction of ERG with chromatin modifiers.The alternative text for this image may have been generated using AI.

A Volcano plot comparing the spectral counts of identified interactors between FLAG-BirA-ERG WT and P199L. The background color indicates the prey FCA P199L/WT ratio. Significant proteins were selected with a P < 0.08 cutoff based on spectral count ratios. Notable proteins are colored according to molecular function. B Mean spectral counts for NCOR-HDAC3 hits (averaged between two biological replicates). Saint scores and bFDR are >0.8 and <0.05, respectively. FCA—fold-change. SC—spectral counts. Source data are provided as a Source Data file.

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