Fig. 6: ERG affects chromatin modifications at myeloid-related gene loci.

A Global annotation statistics on the enrichment of ChIP signal of H3K27ac across groups. B Heatmap hierarchical clustering (left panel) and metagene plots (right panel) showing H3K27ac peaks of downregulated and hypoacetylated DEG following expression of WT-ERG force in Hoxb8 cells. C The intensity signal of normalized read counts of histone peaks is presented for genes identified in B (unpaired Wilcoxson test, P-value = 2.2 × 10⁻¹⁶). D GO analysis based on the nearest transcription start site to peaks identified in B. Adjusted P-values are displayed. E Heatmap hierarchical clustering centered on H3K27ac peaks associated with genes identified in B. The co-occupancy for H3K4me1, H3K4me3 and H3K9ac marks is shown. F Track example for two genes identified in B and D—Ly6c2 (Gr1) and Clec12a. Dashed black boxes indicate regions of H3K4me1 and H3K27ac overlap, and dashed red boxes indicate regions that relate to the transcription start site (H3K4me3, H3K9ac, and H3K27ac overlap). Source data are provided as a Source Data file.