Fig. 5: Conditional deletion of α2δ−1 from ACC→DMS neurons increases effort exertion without affecting the learning of instrumental actions.
From: Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control
a Schematic representation of the injection strategy to conditionally knock out α2δ−1. b Lever press rate for the 9 days on the FR schedule for α2δ−1 (+/+) and α2δ−1(f/f) mice. c Schematic representation of the progressive ratio (PR) schedule. The value (n) of the ratio (R) increment of 5 for every received reward (i), starting with R = 1. d Representative peri-reward raster histograms of LP for both groups. e Cumulative reward count over the PR session for α2δ−1 (+/+) and α2δ−1(f/f) animals. f Breakpoint for α2δ−1(+/+) and α2δ−1(f/f) animals. g Left: Schematic representation of the Extinction schedule in which the action is not reinforced. Right: Normalized lever press number in a 3 min bins for α2δ−1 (+/+) and α2δ−1(f/f) animals. h Left: Schematic representation of the omission schedule in which the reinforcer is delayed by each press. Right: The lever press/min are reported for the 2 days of testing (dashed line). i Schematic representation of the devaluation test schedule. j Lever press/min in valued and devalued states after pre-feeding. Source data are provided as a Source Data file. Drawings in (a, c, g, h) are created with BioRender.com.
