Fig. 4: NMT inhibitors show minimal toxicity in human hepatoma cells and reduce Plasmodium falciparum blood-stage development. | Nature Communications

Fig. 4: NMT inhibitors show minimal toxicity in human hepatoma cells and reduce Plasmodium falciparum blood-stage development.

From: Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts

Fig. 4

a Percentage of live HepG2 cells after 48-hour treatment with each NMT inhibitor (shown in black) compared with that of controls treated with diluent. Data are presented as mean values ± SD. The staurosporine-positive control is shown in red. b–d Percentage change in P. falciparum blood-stage development as measured by parasite DNA level fluorescence assay after 72-hour treatment with NMT inhibitors from each of the three prioritized compound families. Data are normalized to untreated controls set at 100%. Source data are provided as a Source Data file.

Back to article page