Table 4 Replication analysis for three model-derived measures (main effects across drug conditions), average Q-value across options, chosen – unchosen Q-value, and model-derived prediction error

From: Dopamine regulates decision thresholds in human reinforcement learning in males

Contrast / Region

Coordinates

Peak T-value

p(FWE)SVC

Average Q-value

    vmPFC

−6 48 −2

5.06

.002

Chosen-unchosen value

   

    vmPFC / mOFC

6 24 −12

4.09

.033

Reward prediction error

    Left ventral striatum

−9 9 −9

5.95

<.001

    Right ventral striatum

12 9 −10

4.92

.003

    vmPFC / mOFC

−6 32 −15

4.19

.027

    vmPFC

−6 54 3

4.08

.036

  1. Small volume correction for multiple comparisons (SVC) used an a priori region of interest mask across two meta-analyses of reward value effects97,98 (see methods section).
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