Fig. 3: MKP1 is required to promote inflammatory infiltrates in livers of NASH diet fed mice. | Nature Communications

Fig. 3: MKP1 is required to promote inflammatory infiltrates in livers of NASH diet fed mice.

From: MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention

Fig. 3

Mkp1fl/fl and MKP1-LKO mice were fed with CSAA or CDAA diet for 22 weeks. a and d Staining of CD45 and CD68 in liver sections from CSAA or CDAA fed Mkp1fl/fl and MKP1-LKO mice. Scale bar = 20 μm. b, e Quantitation of percentage of CD45 and CD68-positive cells in livers from (a) and (d). c, f mRNA expression of CD45 and CD68 in livers from CSAA or CDAA fed Mkp1fl/fl and MKP1-LKO mice. Data represent the mean ± SEM derived from 6 mice per group. p-values were determined by two-way ANOVA.

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