Fig. 5: Custom pathway-analysis utilizing the interpreted BINNs. | Nature Communications

Fig. 5: Custom pathway-analysis utilizing the interpreted BINNs.

From: Interpreting biologically informed neural networks for enhanced proteomic biomarker discovery and pathway analysis

Fig. 5: Custom pathway-analysis utilizing the interpreted BINNs.The alternative text for this image may have been generated using AI.

The graph underlying the interpreted BINNs can be extracted and subsetted for custom pathway analysis. a The down-stream graph originating from CD14 in the AKI-BINN. The most important contribution of CD14 is to caspase activation via death receptors, MyD88 deficiency, and subsequently, disease and programmed cell death. b The up-stream graph originating from plasma lipoprotein remodeling. Its most important contributor is LDL remodeling, HDL remodeling and four apolipoproteins: APOB, APOA1, APOA4, and APOA2. c The down-stream graph originating from GELS in the COVID-BINN. GELS eventually connects to programmed cell death, sensory perception, immune system, and metabolism of proteins where programmed cell death and immune system are the most important high-level processes and sensory perception has little impact on the network. Source data for all panels are provided as a Source Data file.

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