Fig. 4: Predicted interaction network of proteins encoded by the top prioritised genes from known and novel European GWAS loci.

Protein-protein interaction analysis carried out in STRING v11.5; nodes coloured red represent the GO term ‘Regulation of immune system process’ (GO:0002682) for which 28/1514 proteins are included (FDR P = 1 × 10−9). Full results for all identified pathways are available in Supplementary Data 12.