Table 1 Results of conditional SKAT-O analysis, involving the removal of the two variants that showed genome-wide significance in the single-variant analyses (23:66197712:C:T and 23:66604439:G:A)
From: Analysis of 72,469 UK Biobank exomes links rare variants to male-pattern hair loss
Gene | P | Pconditioned | |
|---|---|---|---|
Continuous model | HEPH | 7.3 × 10−9 | 1.3 × 10−4 |
EDA2R | 1.4 × 10−8 | 0.84 | |
All-model | HEPH | 1.5 × 10−7 | 1.3 × 10−2 |
EDA2R | 1.4 × 10−7 | 0.79 | |
Two-as-control model | HEPH | 1.7 × 10−7 | 2.8 × 10−5 |
EDA2R | 5.9 × 10−6 | 0.81 | |
Extreme model | HEPH | 2.0 × 10−7 | 5.7 × 10−6 |
EDA2R | 8.0 × 10−5 | 0.12 |
