Table 1 APRs identified by TANGO in E. coli TEM β-lactamase (UniProt Accession BLAT_ECOLX) and the resulting peptides tested

From: Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

#

Position

APR

TANGO score

Length

Adjusted APR

Peptide sequence

1

12

FFAAFC

46.5

6

FFAAFCL

RFFAAFCLRRPRFFAAFCLRR

2

134

LLLTTI

43.6

6

LLLTTIG

RLLLTTIGRRPRLLLTTIGRR

3

145

LTAFL

31.9

5

LTAFLHN

RLTAFLHNRRPRLTAFLHNRR

4

195

LLTLA

18.9

5

LLTLAS

RLLTLASRRPRLLTLASRR

5

224

AGWFIA

14.5

6

AGWFIA

RAGWFIARRPRAGWFIARR

6

242

IIAAL

11.1

5

GIIAALG

RGIIAALGRRPRGIIAALGRR

7

255

IVVIYTT

78.9

7

IVVIYTT

RIVVIYTTRRPRIVVIYTTRR