Table 2 MIC values of the TEM peptides as well as penicillin in the presence of peptide or tazobactam for E. coli strain UZ_TEM104

From: Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

Peptide

MIC peptide (μg/mL)

Concentration of additive (μg/mL)

MIC penicillin (μg/mL)

None (buffer)

0

1600

TEM1.0

>100

50

1600

TEM2.0

>100

50

800

TEM3.0

>100

50

200

TEM4.0

100

50

1600

TEM5.0

100

50

1600

TEM6.0

>100

50

1600

TEM7.0

>100

50

1600

Tazobactam

50

400

Tazobactam + TEM3.0

25 + 25

50