Table 3 MIC values of penicillin for various clinical isolates of E. coli in the absence or presence of 30 μg/mL of peptide TEM3.2

From: Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

Year collected

Country of origin

Infection

Organ

β-lactamase

MIC ampicillin

MIC ampicillin + 30 µg/mL TEM-3.2

NA

NA

NA

 

TEM-1

>64

≤0.06

NA

NA

NA

 

TEM-1

>64

≤0.06

NA

NA

NA

 

TEM-1

>64

≤0.06

2016

South Africa

IAI

Peritoneal Fluid

TEM-ESBL

>64

≤0.06

2016

South Africa

IAI

Peritoneal Fluid

TEM-ESBL

>64

≤0.06

2016

Germany

UTI

Urine

TEM-ESBL

>64

≤0.06

2017

Israel

UTI

Urine

TEM-ESBL

>64

≤0.06

2017

Portugal

RTI

Bronchi

TEM-ESBL

>64

0.5

2016

Lithuania

UTI

Urine

TEM-ESBL

>64

1

2017

Germany

RTI

Bronchi

SHV-12; TEM-ESBL;

>64

0.12

2017

Turkey

UTI

Urine

SHV-2; CTX-M-55; VIM-1;

>64

≤0.06

2017

Turkey

IAI

Abscess

TEM-ESBL; CTX-M-24; OXA-48

>64

≤0.06

2017

France

IAI

Peritoneal Fluid

TEM-ESBL; CTX-M-TYPE;

>64

≤0.06

2017

Romania

UTI

Urine

TEM-ESBL; CTX-M-27;

>64

≤0.06

2017

Qatar

UTI

Urine

TEM-ESBL; CTX-M-15; NDM-5;

>64

>64

2017

Qatar

IAI

Abscess

TEM-ESBL; CTX-M-15; NDM-19;

>64

>64

  1. UTI urinary tract infection, IAI intra-abdominal infection, RTI respiratory tract infection.