Fig. 4: The serial translocation SV with KIT introgressed from cattle contributed to white coat colours of yaks.
From: Evolutionary origin of genomic structural variations in domestic yaks
a Scans of chromosomes 6 and 25 of the association with coat colour and of FST and XP-CLR values for black vs white yaks (red: SNPs; blue: SVs). b Chromatin interaction heatmap based on Hi-C sequencing data of white yak and BosMut3.0 (black phenotype), respectively, using the BosMut3.0 genome as a reference. Black triangles indicate topologically associating domain (TAD). The BC fragment shows the strongest reciprocal signal within TAD. The bar graph block indicates the A/B compartment. Positive eigen values indicate A-compartment, corresponding to transcriptional activation regions. Negative eigen values indicate B-compartment, which correspond to closed chromatin regions. c Relative mRNA expression level and (d) FPKM of KIT in the ear tissue of black (n = 6) and white yaks (n = 6). Values are shown as means ± SD; Exact p-values are shown; two-sided Student’s t-test. e–g The introgression between domestic yaks and colour-sided cattle with the NJ trees on SNPs of the phased KIT nearby ±10 kb, BC and βγ haplotype, respectively. h The most likely histories of the white and colour-sided yaks. Cs6: the allele on chromosome 6 of colour-sided yaks and cattle. SCs6: the allele on chromosome 6 of white yaks. Wt6/25: Wild-type allele on chromosome 6 or 25 of black and colour-sided yaks. Wt6/29: Wild-type allele on chromosome 6 or 29 of cattle. Chromosomes 6 and 25 of the yaks are homologous to chromosomes 6 and 29 of the cattle, respectively. Source data are provided as a Source Data file.
