Table 2 Validation of MR association between risk factors and skin cancer risk using SNP instruments derived from independent non-overlapping subset of UKB
From: Uncovering the complex relationship between balding, testosterone and skin cancers in men
Cancer outcome | Risk factors | With all SNP instruments identified from entire UKB cohort | With only SNP instruments that has p < 1e−5 in independent UKB dataset | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
\({P}_{{UKB}}\) | \(O{R}_{{UKB}}\) | \({P}_{{QSKIN}}\) | \(O{R}_{{QSKIN}}\) | \({P}_{{META}}\) | \(O{R}_{{META}}\) | \({P}_{{UKB}}\) | \(O{R}_{{UKB}}\) | \({P}_{{QSKIN}}\) | \(O{R}_{{QSKIN}}\) | \({P}_{{META}}\) | \(O{R}_{{META}}\) | ||
all KC | MPB | 1.45E-04 | 1.17 (1.08 to 1.27) | 0.78 | 1.03 (0.85 to 1.24) | 2.94E-04 | 1.15 (1.06 to 1.23) | 3.86E-03 | 1.16 (1.05 to 1.28) | 0.35 | 1.11 (0.89 to 1.37) | 2.61E-03 | 1.15 (1.05 to 1.26) |
TotalT | 0.83 | 1.01 (0.93 to 1.1) | 0.3 | 1.15 (0.88 to 1.5) | 0.61 | 1.02 (0.94 to 1.10) | 0.81 | 1.01 (0.93 to 1.10) | 0.32 | 1.15 (0.87 to 1.52) | 0.6 | 1.02 (0.94 to 1.11) | |
FreeT | 0.61 | 0.96 (0.83 to 1.12) | 0.89 | 0.97 (0.66 to 1.44) | 0.6 | 0.96 (0.84 to 1.11) | 0.61 | 0.96 (0.81 to 1.13) | 0.74 | 0.94 (0.63 to 1.39) | 0.55 | 0.95 (0.82 to 1.11) | |
SHBG | 0.22 | 1.05 (0.97 to 1.12) | 0.59 | 1.05 (0.88 to 1.24) | 0.18 | 1.05 (0.98 to 1.12) | 0.22 | 1.05 (0.97 to 1.12) | 0.59 | 1.05 (0.88 to 1.25) | 0.18 | 1.05 (0.98 to 1.12) | |
BCC | MPB | 1.84E-03 | 1.15 (1.05 to 1.26) | 0.49 | 1.1 (0.84 to 1.43) | 1.32E-03 | 1.15 (1.06 to 1.25) | 0.02 | 1.14 (1.02 to 1.28) | 0.31 | 1.17 (0.87 to 1.58) | 0.01 | 1.15 (1.03 to 1.27) |
TotalT | 0.37 | 1.04 (0.95 to 1.15) | 0.29 | 1.18 (0.86 to 1.62) | 0.25 | 1.06 (0.96 to 1.15) | 0.45 | 1.04 (0.94 to 1.15) | 0.5 | 1.12 (0.81 to 1.55) | 0.36 | 1.05 (0.95 to 1.15) | |
FreeT | 0.85 | 0.98 (0.83 to 1.16) | 0.75 | 0.93 (0.57 to 1.5) | 0.78 | 0.98 (0.84 to 1.14) | 0.77 | 0.97 (0.81 to 1.17) | 0.54 | 0.87 (0.55 to 1.37) | 0.62 | 0.96 (0.81 to 1.14) | |
SHBG | 0.13 | 1.07 (0.98 to 1.16) | 0.39 | 1.11 (0.88 to 1.39) | 0.08 | 1.07 (0.99 to 1.15) | 0.12 | 1.07 (0.98 to 1.16) | 0.35 | 1.11 (0.89 to 1.40) | 0.08 | 1.07 (0.99 to 1.16) | |
SCC | MPB | 2.35E-06 | 1.31 (1.17 to 1.46) | 0.65 | 1.08 (0.77 to 1.53) | 4.25E-06 | 1.28 (1.15 to 1.43) | 1.33E-04 | 1.29 (1.13 to 1.48) | 0.48 | 1.15 (0.77 to 1.72) | 1.19E-04 | 1.28 (1.13 to 1.45) |
TotalT | 0.24 | 0.92 (0.81 to 1.05) | 0.31 | 1.24 (0.82 to 1.87) | 0.41 | 0.95 (0.84 to 1.08) | 0.49 | 0.95 (0.83 to 1.09) | 0.42 | 1.19 (0.77 to 1.84) | 0.68 | 0.97 (0.85 to 1.11) | |
FreeT | 0.46 | 0.92 (0.75 to 1.14) | 0.82 | 1.07 (0.58 to 1.99) | 0.54 | 0.94 (0.77 to 1.15) | 0.59 | 0.94 (0.77 to 1.16) | 0.79 | 1.09 (0.57 to 2.09) | 0.67 | 0.96 (0.78 to 1.17) | |
SHBG | 0.92 | 0.99 (0.9 to 1.1) | 0.99 | 1.00 (0.74 to 1.36) | 0.93 | 1.00 (0.90 to 1.10) | 0.86 | 0.99 (0.90 to 1.10) | 0.96 | 1.01 (0.74 to 1.37) | 0.88 | 0.99 (0.90 to 1.09) | |
Melanoma | MPB | – | – | – | – | 0.84 | 0.99 (0.91 to 1.08) | – | – | – | – | 0.38 | 0.96 (0.88 to 1.05) |
TotalT | – | – | – | – | 0.29 | 0.94 (0.84 to 1.05) | – | – | – | – | 0.34 | 0.94 (0.84 to 1.06) | |
FreeT | – | – | – | – | 0.91 | 0.99 (0.81 to 1.20) | – | – | – | – | 0.84 | 0.98 (0.78 to 1.22) | |
SHBG | – | – | – | – | 0.22 | 0.95 (0.88 to 1.03) | – | – | – | – | 0.25 | 0.95 (0.88 to 1.03) | |
