Table 3 Comparison of estimated MR body-site-specific association between MPB and skin cancer in the UK and Australian population
From: Uncovering the complex relationship between balding, testosterone and skin cancers in men
Cancer outcome by anatomical category | Study (UK) | \({Ncase}{s}_{{UK}}\) | \({P}_{{UK}}\) | \(O{R}_{{UK}}\) | Study (Aus) | \({Ncase}{s}_{{Aus}}\) | \({P}_{{Aus}}\) | \(O{R}_{{Aus}}\) | Fixed-effect meta | |
|---|---|---|---|---|---|---|---|---|---|---|
\({P}_{{META}}\) | \(O{R}_{{META}}\) | |||||||||
Head and neck region | ||||||||||
Melanoma (all MPB variant) | UKB | 390 | 0.17 | 1.20 (0.92 to 1.57) | MIA | 537 | 0.02 | 1.48 (1.07 to 2.04) | 0.01 | 1.31 (1.07 to 1.61) |
Melanoma (MPB exc. outlier) | UKB | 390 | 0.24 | 1.18 (0.90 to 1.54) | MIA | 537 | 0.10 | 1.30 (0.95 to 1.76) | 0.05 | 1.23 (1.00 to 1.50) |
SCC (all MPB variant) | UKB | 1427 | 0.27 | 0.92 (0.80 to 1.07) | QSKIN | 184 | 0.94 | 0.99 (0.65 to 1.49) | 0.29 | 0.93 (0.81 to 1.06) |
SCC (MPB exc. outlier) | UKB | 1427 | 0.28 | 0.92 (0.80 to 1.07) | QSKIN | 184 | 0.52 | 0.87 (0.57 to 1.32) | 0.22 | 0.92 (0.80 to 1.05) |
BCC (all MPB variant) | UKB | 4768 | 0.12 | 1.07 (0.98 to 1.16) | QSKIN | 439 | 0.12 | 1.25 (0.94 to 1.67) | 0.05 | 1.08 (1.00 to 1.17) |
BCC (MPB exc. outlier) | UKB | 4768 | 0.34 | 1.11 (0.90 to 1.37) | QSKIN | 439 | 0.36 | 1.14 (0.86 to 1.51) | 0.08 | 1.08 (0.99 to 1.17) |
Upper limb/Arm region | ||||||||||
Melanoma (all MPB variant) | UKB | 446 | 0.01 | 0.72 (0.57 to 0.93) | MIA | 280 | 0.59 | 1.10 (0.78 to 1.55) | 0.08 | 0.84 (0.68 to 1.02) |
Melanoma (MPB exc. outlier) | UKB | 446 | 0.01 | 0.71 (0.56 to 0.92) | MIA | 280 | 0.72 | 0.94 (0.68 to 1.31) | 0.02 | 0.79 (0.65 to 0.97) |
SCC (all MPB variant) | UKB | 284 | 0.75 | 1.05 (0.77 to 1.44) | QSKIN | 149 | 0.53 | 1.16 (0.73 to 1.86) | 0.54 | 1.08 (0.84 to 1.41) |
SCC (MPB exc. outlier) | UKB | 284 | 0.91 | 1.02 (0.74 to 1.40) | QSKIN | 149 | 0.92 | 1.02 (0.64 to 1.63) | 0.88 | 1.02 (0.78 to 1.32) |
BCC (all MPB variant) | UKB | 636 | 0.47 | 0.93 (0.75 to 1.14) | QSKIN | 248 | 0.49 | 1.15 (0.78 to 1.68) | 0.77 | 0.97 (0.81 to 1.17) |
BCC (MPB exc. outlier) | UKB | 636 | 0.36 | 0.91 (0.73 to 1.12) | QSKIN | 248 | 0.99 | 1.00 (0.69 to 1.46) | 0.43 | 0.93 (0.77 to 1.12) |
Trunk region | ||||||||||
Melanoma (all MPB variant) | UKB | 708 | 0.20 | 0.89 (0.75 to 1.06) | MIA | 1060 | 0.97 | 1.00 (0.78 to 1.30) | 0.30 | 0.93 (0.80 to 1.07) |
Melanoma (MPB exc. outlier) | UKB | 708 | 0.15 | 0.88 (0.74 to 1.05) | MIA | 1060 | 0.81 | 0.97 (0.76 to 1.24) | 0.19 | 0.91 (0.79 to 1.05) |
SCC (all MPB variant) | UKB | 209 | 0.74 | 1.05 (0.77 to 1.43) | QSKIN | 23 | 0.98 | 0.99 (0.32 to 3.03) | 0.76 | 1.05 (0.78 to 1.41) |
SCC (MPB exc. outlier) | UKB | 209 | 0.92 | 1.02 (0.74 to 1.39) | QSKIN | 23 | 0.71 | 0.81 (0.26 to 2.51) | 1.00 | 1.00 (0.74 to 1.35) |
BCC (all MPB variant) | UKB | 1350 | 0.14 | 1.11 (0.97 to 1.28) | QSKIN | 209 | 0.90 | 0.97 (0.66 to 1.45) | 0.18 | 1.10 (0.96 to 1.25) |
BCC (MPB exc. outlier) | UKB | 1350 | 0.21 | 1.10 (0.95 to 1.26) | QSKIN | 209 | 0.73 | 0.93 (0.63 to 1.39) | 0.28 | 1.08 (0.94 to 1.23) |
Lower limb region | ||||||||||
Melanoma (all MPB variant) | UKB | 239 | 0.27 | 0.84 (0.62 to 1.14) | MIA | 361 | 0.55 | 0.90 (0.65 to 1.26) | 0.22 | 0.87 (0.69 to 1.09) |
Melanoma (MPB exc. outlier) | UKB | 239 | 0.33 | 0.86 (0.63 to 1.17) | MIA | 361 | 0.55 | 0.93 (0.72 to 1.19) | 0.17 | 0.85 (0.68 to 1.07) |
SCC (all MPB variant) | UKB | 109 | 0.60 | 0.88 (0.56 to 1.39) | QSKIN | 102 | 0.48 | 1.24 (0.68 to 2.26) | 1.00 | 1.00 (0.70 to 1.43) |
SCC (MPB exc. outlier) | UKB | 109 | 0.66 | 0.90 (0.57 to 1.42) | QSKIN | 102 | 0.93 | 0.98 (0.55 to 1.75) | 0.69 | 0.93 (0.65 to 1.33) |
BCC (all MPB variant) | UKB | 269 | 0.85 | 1.03 (0.76 to 1.39) | QSKIN | 93 | 0.63 | 0.87 (0.49 to 1.54) | 0.95 | 0.99 (0.76 to 1.30) |
BCC (MPB exc. outlier) | UKB | 269 | 0.90 | 1.02 (0.75 to 1.39) | QSKIN | 93 | 0.27 | 0.72 (0.40 to 1.29) | 0.69 | 0.95 (0.72 to 1.24) |
