Fig. 8: Illustration of MB-regulated tau phase transition.

a Activity of MB in the phase transition of tau. MB inhibits aggregation of free tau and transition of gelated droplets to aggregates. In contrast, MB promotes LLPS and the liquid-to-gel transition of tau. b Schematic illustration of MB-tau interactions during the phase transition process. MB binds to tau, inducing slight conformational changes in tau. Upon phase separation, tau undergoes significant conformational expansion and MB may bridge interactions between tau molecules.