Table 3 SNP-heritability estimation for Asian typical nAMD and PCV, and genetic correlation

From: Contribution of common and rare variants to Asian neovascular age-related macular degeneration subtypes

Phenotype

SNP-h2

Genetic correlation

Observed scale

Liability scale

 

h2

SE

h2

SE

rg

SE

P

PCV

0.417

0.121

0.287

0.083

0.666

0.187

\(4.00\times {10}^{-4}\)

Typical nAMD

0.386

0.147

0.264

0.101

  1. We conducted heritability and genetic correlation analyses using the LD score regression method, applying GWAS summary statistics from 1555 cases with PCV, 1573 cases with typical nAMD and 5493 controls. We retained variants that, after merging with a Hapmap3 SNP list, had a minor allele frequency \(\ge 1\%\) and an imputation quality info \( > 0.8\). We calculated both observed and liability scale SNP-h2, taking into account the \(0.5\%\) AMD prevalence in Asian populations27,28.
  2. nAMD neovascular AMD, PCV polypoidal choroidal vasculopathy, h2 heritability estimate, SE standard error, rg genetic correlation estimate.
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