Fig. 4: In vivo imaging of αvβ6 (+) A431 tumors using fluorescently labeled B6_BP. | Nature Communications

Fig. 4: In vivo imaging of αvβ6 (+) A431 tumors using fluorescently labeled B6_BP.

From: De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

Fig. 4: In vivo imaging of αvβ6 (+) A431 tumors using fluorescently labeled B6_BP.The alternative text for this image may have been generated using AI.

a Athymic nude mice were injected with αvβ6 (+) A431 cells on the left shoulder and αvβ6 (−) HEK293T cells on the right shoulder. AlexaFluor-680-labeled B6_BP (AF680-B6_BP) was injected via the tail vein to image the tumors over time as indicated (see Supplementary for additional images, n = 5). b Semiquantitative ex vivo biodistribution assay of AF-680-B6_BP at 6 h post-tail vein injection. B6_BP selectively accumulates in αvβ6 (+) tumors and primarily clears via glomerular filtration in the kidneys. Data are presented as mean values +/− SD, n = 5 mice.

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