Fig. 6: Antiproliferative activities of selected atropisomeric indoles and further chemical modifications. | Nature Communications

Fig. 6: Antiproliferative activities of selected atropisomeric indoles and further chemical modifications.

From: All-round catalytic and atroposelective strategy via dynamic kinetic resolution for N-/2-/3-arylindoles

Fig. 6

a Antiproliferative activities of the racemic mixtures of selected atropisomeric indoles. aAll values are the means of at least three experiments. Measured by the Sulforhodamine-B (SRB) method. Data are represented as means ± SEM. b Antiproliferative activities of 3ma and ent-3ma. The results are representative of three independent experiments. Measured by the SRB method. Data are represented as means ± SD. c One-mmol-scale reaction and chemical derivatization of product. A549: Human lung cancer cell line; HCT116: Human colon cancer cell line; MDA-MB-231: Human breast cancer cell line; SK-Hep-1: Human liver cancer cell line; SNU-638: Human stomach cancer cell line; MRC-5: Normal human lung fibroblast cell line.

Back to article page