Table 1 Incident lymphoid and myeloid malignancy associations (HR) with 95% confidence intervals by CH status
From: Shared and distinct genetic etiologies for different types of clonal hematopoiesis
Malignancy | CH status | NCancer | NNo_cancer | HR (95% CI) | p-valuea |
|---|---|---|---|---|---|
Lymphoid | |||||
No LOY, LOX, CHIP, or Autosomal mCAs | 919 | 163,193 | REF | – | |
LOY only | 169 | 15,458 | 1.03 (0.86–1.23) | 7.67 × 10−1 | |
LOX only | 41 | 4620 | 1.46 (1.06–2.01) | 2.09 × 10−2 | |
CHIP only | 51 | 5837 | 1.19 (0.90–1.58) | 2.32 × 10−1 | |
Autosomal mCA only | 186 | 5198 | 5.24 (4.47–6.14) | 2.89 × 10−93 | |
LOY and CHIP | 7 | 727 | 0.86 (0.41–1.81) | 6.83 × 10−1 | |
LOY and Autosomal mCA | 40 | 787 | 4.38 (3.16–6.06) | 5.40 × 10−19 | |
LOX and CHIP | 1 | 218 | 0.69 (0.10–4.89) | 7.08 × 10−1 | |
LOX and Autosomal mCA | 20 | 267 | 10.93 (6.98–17.13) | 1.55 × 10−25 | |
CHIP and Autosomal mCA | 26 | 313 | 10.06 (6.80–14.89) | 6.55 × 10−31 | |
LOY, CHIP, and Autosomal mCA | 3 | 71 | 3.36 (1.08–10.49) | 3.64 × 10−2 | |
LOX, CHIP, and Autosomal mCA | 6 | 20 | 41.10 (18.34–92.09) | 1.77 × 10−19 | |
Myeloid | |||||
No LOY, LOX, CHIP, or Autosomal mCAs | 202 | 163,910 | REF | - | |
LOY only | 29 | 15,598 | 0.98 (0.65–1.49) | 9.34 × 10−1 | |
LOX only | 10 | 4651 | 1.48 (0.78–2.83) | 2.30 × 10−1 | |
CHIP only | 49 | 5839 | 5.44 (3.97–7.47) | 9.00 × 10−26 | |
Autosomal mCA only | 55 | 5329 | 7.19 (5.32–9.7) | 6.14 × 10−38 | |
LOY and CHIP | 9 | 725 | 6.14 (3.09–12.2) | 2.19 × 10−7 | |
LOY and Autosomal mCA | 4 | 823 | 2.45 (0.9–6.67) | 7.96 × 10−2 | |
LOX and CHIP | 0 | 219 | - | 9.94 × 10−1 b | |
LOX and Autosomal mCA | 1 | 286 | 2.21 (0.31–15.86) | 4.29 × 10−1 | |
CHIP and Autosomal mCA | 17 | 322 | 31.69 (19.2−52.28) | 1.10 × 10−41 | |
LOY, CHIP, and Autosomal mCA | 1 | 73 | 6.42 (0.89−46.15) | 6.47 × 10−2 | |
LOX, CHIP, and Autosomal mCA | 3 | 23 | 87.29 (27.67−275.35) | 2.45 × 10−14 |
