Fig. 1: Comparative genomics of the Aurora kinase family and known interactors indicate extensive divergence in the molecular regulation of Plasmodium spp. cell division. | Nature Communications

Fig. 1: Comparative genomics of the Aurora kinase family and known interactors indicate extensive divergence in the molecular regulation of Plasmodium spp. cell division.

From: Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages

Fig. 1

A The five locations of Aurora kinase (AK) activity during chromosome segregation in canonical late anaphase mitotic cell progression. The same colour for each subcellular location is used in (B). B Presence-absence matrix of eukaryote mitotic kinases focused on Apicomplexa and AKs, including the scaffolds and activators of this essential kinase family. Right: known or suggested mitotic location of Aurora paralogs and their protein complexes in subgroups exemplified by model systems. A general pattern of sub-functionalisation after gene duplication within the AK family can be discerned: one paralogue interacts with the CPC: Survivin-Borealin-INCENP complex (‘equatorial’), while other paralogues can be found in the cytoplasm, at the spindle pole and/or on spindle MTs (‘polar/other’) (see Supplementary Fig. S1). LECA Last Eukaryotic Common Ancestor.

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